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KMID : 1134820200490070653
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 7 p.653 ~ p.658
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Anti-Atopic Effect of DNCB-Induced Mouse in Chondrus canaliculatus Ethanol Extracts
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Kang Woo-Sin
Jeong So-Mi
Ryu Si-Hyeong
Xu Xiaotong
Lee Ji-Eun
Ahn Dong-Hyun
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Abstract
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Atopic dermatitis (AD) is a chronic inflammatory skin disease that manifests as itching and skin dryness. The condition is induced by complex conditions and mechanisms, involving the increased production of helper T cell 2 lymphocytes (Th2), basophil, and immunoglobulin E; the pro-inflammatory cytokines are closely related. Chondrus canaliculatus is a red algae that lives mainly in the intertidal regions, but the C. canaliculatus ethanol extract (CCEE) has never been reported for atopic studies. Therefore, this study examined the anti-atopic dermatitis effects of CCEE in 2,4-dinitrochlorobenzene-induced mouse models. The prevention effect of CCEE on atopic dermatitis was tested by measuring the clinical severity score of the skin, cytokine secretion, and splenocyte-proliferation ability. As a result, the AD symptoms in the CCEE treatment group were suppressed more than in the positive control. Moreover, the application of CCEE reduced the degree of skin lesions and the pro-inflammatory cytokines (interleukin-4, interferon-γ) level. These results suggest that CCEE may be effective in preventing atopic dermatitis and may have therapeutic potential as an atopic dermatitis agent and cosmeceutical.
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KEYWORD
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Chondrus canaliculatus, atopic dermatitis, anti-atopy, IFN-γ, IL-4
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